L-Methylfolate Calcium is the biologically active form of folate (Vitamin B9), readily utilized by the body without enzymatic conversion.
It plays a critical role in DNA synthesis, methylation pathways, neurotransmitter production, and homocysteine metabolism. L-Methylfolate Calcium is preferred in pharmaceutical and premium nutraceutical formulations, especially for individuals with MTHFR polymorphisms.
1. PRODUCT IDENTIFICATION
| Chemical Name | Calcium (6S)-5-methyltetrahydrofolate |
| Synonyms | L-5-MTHF Calcium, (6S)-5-Methyltetrahydrofolate Calcium Salt |
| CAS No. | 151533-22-1 |
| Molecular Formula | C₂₀H₂₃CaN₇O₆ |
| Molecular Weight | ~497.5 g/mol |
2. PRODUCT DESCRIPTION
L-Methylfolate Calcium supports methylation processes, neurotransmitter synthesis, and cardiovascular health, making it ideal for prenatal, neurological, and metabolic formulations.
3. GRADE
- Pharmaceutical Grade
- Nutraceutical / Food Grade
(Grade supplied as per customer specification.)
4. AVAILABLE FORM
White to pale yellow color powder
5. TECHNICAL SPECIFICATIONS
| Appearance | Light yellow to yellow crystalline powder |
| Identification | Conforms |
| Assay (L-Methylfolate, dry basis) | 95.0 – 102.0% |
| Loss on Drying | ≤ 7.0% |
(Specifications may be aligned to USP / EP or customer-approved standards.)
6. PHYSICOCHEMICAL PROPERTIES
- Solubility: Slightly soluble in water
- Stability: Sensitive to light and moisture
7. APPLICATIONS
Pharmaceuticals- Adjunct therapy for depression
- Hyperhomocysteinemia management
- Prenatal and neurological formulations
- Active folate supplements
- Women’s health and prenatal nutrition
- Cardiovascular and cognitive support
- Targeted methylation support formulations
8. REGULATORY & COMPLIANCE
- Manufactured in GMP-certified facilities
- Complies with applicable IH standards
- Food-grade compliant with relevant food regulations
- Non-GMO
- BSE/TSE Free
- Allergen Free
Documents Available:
- Certificate of Analysis (CoA)
- MSDS / SDS
- Stability data
- Manufacturing flow chart (on request)
9. PACKAGING
- Standard: 25 kg LDPE bag
- Bulk: 25 kg HDPE drum with double LDPE liner
- Custom packaging available on request
10. STORAGE & SHELF LIFE
- Store at 2–8°C, protected from light and moisture
- Keep container tightly closed
- Shelf Life: 24 months under recommended storage conditions
11. SAFETY INFORMATION
- For professional use only
- Avoid exposure to light, heat, and humidity
- Use appropriate PPE
- Refer to MSDS for detailed safety information
12. COMMERCIAL INFORMATION
- MOQ: As per grade and packaging
- Lead Time: 7 days
- Supply Capability: Bulk and contract manufacturing
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